Our fluorinated intermediates can be used to enhance the biological properties of a wide range of pharmaceuticals and agrochemicals, making it easy to add the valuable properties of the C-F bond to a variety of biologically active molecules.

Physical, chemical, and biological properties of compounds including surface energies, reactivity, polarity, and thermal stability can be greatly altered by the substitution of one or more fluorine atoms. Thus, it's not surprising that the positive effects of fluorine are found in over 20% of pharmaceuticals and over 30% of agrochemicals under development.

Incorporating fluorine into a bioactive pharmaceutical or agricultural compound can often improve lipophilicity, reduce toxicity and increase efficacy. Our range of organic building blocks based on CF₂ and CF₃ groups make it safe, simple, and economical to propitiously place fluorine at a particular position in a molecule.

Fluorinated compounds are playing a significant role in the development of new anti-cancer, anti-viral, anti-inflammatory, anti-fertility, and central nervous system drugs among others. In modern crop protection, fluorine containing agrochemicals include herbicides, insecticides, and fungicides.

Selectively fluorinated compounds are being used extensively in the development of new pharmaceuticals and agrochemicals because these compounds exhibit dramatically improved potency when compared to non-fluorinated analogues. This often results in cost savings and smaller dosage requirements.

Please click on the appropriate chemical intermediate to review the technical datasheet:

• Tetrachloropropane (TCP) - TCP is a selectively chlorinated propane that is used as an industrial chemical to produce easily alterable products. The unique position of chlorine allows selective reactions, creating new intermediates for the synthesis of pharmaceutical and agricultural substances.

• Trifluoropropene (TFP) - TFP is a selectively fluorinated low molecular weight propene that is also used as a monomer to produce a high performance silicone elastomer. The double bond on the 1-2 positions make it possible to provide a fluorinated methyl end to the final product.

• Bromotrifluoropropane (TFP Bromide) - TFP Bromide is a selectively fluorinated low molecular weight bromopropane that is useful as an industrial chemical to produce finished products with CF₃ groups.

• Bromodifluoroethane (BDFE) - BDFE is a selectively fluorinated bromoethane that is used to provide a CF₂ end to the final product.

• Bromofluoropropene (BFPe) - BFPe is a selectively fluorinated bromopropene that is used to provide a CF₃ end group to the final product. Its unique structure provides many opportunities for the synthesis of various molecular structures.

Individuals with asthma and chronic obstructive pulmonary disease such as bronchitis or emphysema depend on metered-dose inhalers (MDIs) to deliver medicine to their lungs. Our HFC-227ea medical gas, also known as Heptafluoropropane, is used as a propellant in many MDI formulations to deliver the proper amount of medication. HFC-227ea was developed to replace ozone-depleting compounds such as CFC-11, CFC-12, CFC-114, HCFC-22, and HCFC-142b in aerosol propellant applications.

Manufactured in accordance with current Good Manufacturing Procedures (cGMP) for active pharmaceutical ingredients, HFC-227ea is approved by the U. S. Food and Drug Administration and is compatible with a wide range of medications.

Many of the world's largest pharmaceutical companies have adopted HFC-227ea as part of their changeover to CFC-free inhalers. The vapor pressure, density, and solubility of HFC-227ea are the ideal physical and chemical properties necessary for the proper delivery of medicine.

To review the technical datasheet on high-purity HFC-227ea, please click here.